Saturday, October 5, 2019
Education and Religion Essay Example | Topics and Well Written Essays - 1000 words
Education and Religion - Essay Example As the world continues to reel from the effects brought about by technological change, the religious educational community is now experiencing the challenges associated with the transition to a more learner-personalized, ICT-enabled education. Some questions reflect the search for purpose behind the technology transition: Why do we need to integrate technology into the religiosity? How can technology support learnersââ¬â¢ religious-based educational experiences? How can technology support a more productive future in learning about Judaism? In recent years, there has been notable strategic guidance and investment in ICT initiated and sustained by various First World governments. ICT as a term has been featured as a replacement of ââ¬ËITââ¬â¢. ICT represents the computing and communication facilities and features that are used to assist teaching, learning and a wide array of activities in education (Ager 2003). Other definitions of ICT relate to ICT as a capability or ââ¬Å"l iteracyâ⬠. Based on the discussion of religious-based education, Information Technology (IT) makes up the knowledge, skills, and understanding necessary to utilize information and communication technologies optimally, securely, and meaningfully across the contexts of learning, work, and daily life. Similarly, ICT is referred to as"literacy" by the Programme for International Student Assessment (PISA) and is defined as: "the interest, attitude, and ability of students to appropriately use digital technology and communication tools to access, manage, integrate and evaluate information, construct new knowledge, and communicate with others in order to participate effectively in society". Thus, the integration of ICT into RE only underlines the necessity for acquiring new skills for a new age. In 2004, the first non-statutory nationwide support for teaching REwas started. This has been launched mutually by the QCA, the DCSF, key UK religious groups and RE experts, this framework: "supports the entitlement to RE for all students, regardless of race and civilization; specified national expectations for teaching and learning in RE; and provides guidance for teachers (QCA 2004). What exactly are the activities and outcomes related to quality teaching of Religious Education What about quality learning in learning Judaism Such an inquiry draws even more questions - and not surprisingly, produces multiple perspectives as to what should be deemed as "acceptable" quality of teaching-learning. The impact of ICT on religious students at all the key stages has been highly commendable. It has given them access to a new world of information and knowledge, and guided information as to which is available through their teachers. Annually, research is undertaken to demonstrate enhancement in students' comprehension, skills, and knowledge in ICT use. Religious education contributes to students' social development by giving them an opportunity to reflect on the importance, for believers and others, of a sense of community and belonging. Students have an opportunity to consider how beliefs and values underpin societies and how and why believers and others try to make the world a better place for all. Pupils gain awareness of religious and cultural diversity within society and in other parts of the world (Best 1996). They have an opportunity to consider issues, such as justice, prejudice and extremism, that impact on societies. Establishing Criteria for Quality Teaching and Learning There has been a premium attached to ICT training of all practicing teachers in first world countries. It is encouraging to note that there has been a tremendous growth in the books, online materials, and handbooks for sharing and exchanging ideas, curriculum materials and case studies (Potter 2005). As an outcome, ICT has been gaining steady popularity among teachers/learners specifically for drafting and implementing lesson plans out of the classrooms. RE forums and chat rooms are one of the best ways to share ideas with fellow RE teachers and pick up tips, as are lists of favorite or popular
Friday, October 4, 2019
Computers Essay Example | Topics and Well Written Essays - 750 words
Computers - Essay Example Seeking to explore Dell Computers in holistic analysis, the following will provide a synopsis of the research undertaken on Dell Computers with an eye to the applicability and functuionalisty of this brand of PC. Perusing the site of Dell Computers and looking at the major price points, I determined that the Dell Vostro 220 was the cheapest option of available while the Dell Precision T7500 was the most expensive model on the market. What are the storage requirements for basic application such as Microsoft Office, Adobe Photoshop or Netscape Navigator? Microsoft Office requires a computer and processor of 500 megahertz (MHz) processor or higher; memory which is 256 megabyte (MB) RAM or higher1 and a hard disk space of 1.5 gigabyte (GB). Adobe Photoshop requires a processor which is 1.8GHz or faster, a minimum of 512MB of RAM (1GB recommended) and at least 1GB of available hard-disk space for installation. Finally, Netscape Navigator is no longer on the market, therefore its requirements are irrelevant. The following statement was released by parent company AOL, ââ¬Å"Given AOLs current business focus and the success the Mozilla Foundation has had in developing critically-acclaimed products, we feel its the right time to end development of Netscape branded software. Read the history page for more details about this decision.â⬠(Microsoft, 2009; Adobe 2009; Netscape, 2009). Looking at both the cheapest as well as the most expensive Dell models presently on the market, it is evident that both the Dell Vostro 220 and the high-end Dell Precision T7500 can support basic software applications such as the Microsoft Office and Adobe Photoshop. When you buy a new software package, why does it state the minimum RAM and hard drive space your computer must have for you to run this program? Essentially this sort of information pertains to the amount of available space
Thursday, October 3, 2019
Visiting Forces Agreement Essay Example for Free
Visiting Forces Agreement Essay Thesis Statement: The Philippines should consider terminating its Visiting Forces Agreement (VFA) with the United States before itââ¬â¢s too late for the government to overcome its unexpected dilemma. I.What is the RPââ¬âUS Visiting Forces Agreement? a.A bilateral agreement between the between the Philippines and the United States consisting of two separate agreement documents. a.Balikatan as VFA-1 b.Balikatan as VFA-2 or the Counterpart Agreement II.There are several negative effects of ââ¬Å"Balikatanâ⬠in the country. 1.Balikatan exercises threatened our environment and ecological resources. a.In the past Balikatan exercises, war and combat simulations which involved maneuverings and live fire exercises have caused coral reef destruction and ecological pollution. b.Dumping of toxic wastes and nuclear-powered submarines are very dangerous to the health. 2.Balikatan exercises can affect the peace and order situation in the country. a.Danger to life, honor, safety, and peace of the citizens, like what happened to Nicole (Subic Bay rape victim) and to the other Filipinos threatened since the VFA was signed. 3.Balikatan exercises can affect the industrial and agricultural sector. a.During the dangerous exercises, farmers, fisher folk and indigenous people are banned from attending crops or fishing at the seas, thus, does it affect their livelihood. III.What are other alternatives aside from recent visiting forces agreement? a.Improved the facilities and human forces by setting the international standard in military tactics. b.A new refined and version of visiting forces agreement with the US or other countries that protects the Philippine and international laws on the protection and preservation of the environment.
Stanford Prison Experiment
Stanford Prison Experiment The Stanford Prison Experiment is one of the most notorious and interesting experiments in recent social psychology history. Even though the goals of this experiment were to study the psychological effects of prison on people, it shed some light on how our behaviors can be changed through the roles we participate in. Current research, and role theory, has suggested that roles play a part in our identities and behavior. Parallels between the Stanford Prison Experiment and current research will be studied. A Study on Societal Roles:Ã An Examination of the Stanford Prison Experiment We play many roles in our day to day life: wife, mother, sister, friend, and coworker. Each role has implied duties that we may or may not be so aware of. We work diligently at balancing all of our responsibilities, which if balance is not attained, could lead to dysfunction in a persons life. In order to lead a healthy life, one must examine each role he or she plays. A Stanford social psychology professor, Phillip Zimbardo, was one of the pioneers in exploring social roles, behaviors, and how they are affected by certain situations. His radical research experiment opened up the eyes of the participants and many others as to what we will do in order to fulfill our roles. Zimbardo spent most of his early career conducting behavioral studies that focused on biological processes such as hunger and thirst. It wasnt until the 1960s that he really began to focus on social psychology issues, such as conformity. Philip Zimbardos experiment on prison life demonstrated how quickly a person can dissolve their own identity to fit into the social roles expected of them. The outcome and aftermath of this experiment is still important in current day psychology. First, Zimbardo chose the participants of the experiment to reflect the common or average individuals in the current society. According to Zimbardo, most were college aged, white males, who were from a middle class socioeconomic background (Haney, Banks, Zimbardo, 1973). After random assignment, the prisoner participants were arrested, booked, and then taken to the prison (Zimbardo, Haney, Banks, Jaffe, 1973). In an attempt to make the prison relatively realistic, Zimbardo spent a great deal of time with t he details such as the appearance of the prison and the cells, the uniforms of the guards, and the entry process for the prisoners on the first day. All of these components were planned in an effort to dehumanize, demoralize, and emasculate the prisoners (Zimbardo et al, 1973). The uniforms, weapons, and instructions that the guards received were in an effort to deindividualize them, which effectively displaced their identity, and supported their new authoritative roles (Zimbardo et al, 1973). By day two, the roles were firmly in place in both the prisoners and the guards. After a brief rebellion by the prisoners, the guards felt even more justified in their actions and aggression towards them (Zimbardo et al, 1973). The guards became sadistic, grossly exerting their control to the point of not allowing the prisoners to use the bathroom, instead forcing them to relieve themselves in a bucket that was not removed from the cells (Zimbardo et al, 1973). As time went on, the prisoners s howed signs of acute stress, changes in their mood and behaviors, and started to act in complete obedience to the guards (Zimbardo et al, 1973). The environment in the prison experiment became so dangerous that it was ended before the expected time period of completion. There are many reasons why this experiment was ethically unsuccessful yet rich in information about behaviors and roles. I believe that there were many influences which caused the participants to delve so deeply into their assigned roles. One factor that may have helped to change the participants behaviors was the fact that there was a power hierarchy. Even though this hierarchy was a farce and only part of an experiment, both the guards and the prisoners integrated this perceived imbalance into their identity. The actions, behaviors and attitudes of all involved changed drastically in the six days that the experiment was active. The male participants started off psychologically and physically healthy, as tested before the experiment by Zimbardo (Zimbardo et al, 1973). They soon changed into either sadistic, aggressive guards or anxious, compliant prisoners (Zimbardo et al, 1973). Outside people, who were loosely involved in the experiment, also performed certain roles. Both a priest and lawyer were contacted near the end of the experiment and both acted as though the prisoners were incarcerated in a real jail (Zimbardo et al, 1973). Zimbardo also admitted that his role as Superintendent became very realistic to him (1973). I believe other factors may have also affected the participants: the environment, the presence of the Warden and Superintendent, and the emotional environment within the experiment. Almost every person who came into contact with this experiment changed their point of view to yield to the success of the experiment; all becoming actors in a pretend, simulated situation. It took the experiments premature ending to remind everyone of their own identities, and that this was supposed to be a scientific study. This experiment, while only intending to study a small microcosm of human behavior, uncovered truths that may explain our behaviors in a much broader sense. The Stanford Prison Experiment has far reaching implications. Even though his study focused on a prison environment, the change in behaviors and attitudes due to our social roles can be seen in everyday life. In order to fully understand how our roles affect our behavior, we must first examine what comprises a role. A role is a set of norms that define how people should behave (Myers, 2008, p. 128). Role theory is concerned with studying patterned and characteristic social behaviors, parts or identities that are assumed by social participants, and scripts or expectations for behavior that are understood by all and adhered to by performers (Biddle, 1986, p.68). According to role theory, social attitudes can affect how we behave and even how we define ourselves. An interesting way to view the interactions of our various roles is to organize them into a classification system, similar to what is seen in Biology. What starts as a broad classification, such as our culture and gender, can t hen be reduced into smaller classifications such as local affiliations. All of these roles interact with each other and affect our daily lives. For example, I am a female in an individualistic culture. Each of those categories comes with certain expectations. Life would be vastly different for me if I were to be a female in a collectivistic society. Just one change in the hierarchy could change the subsequent roles that appear in my life. The study of roles and behaviors has been applied to many subjects. Many studies have been completed on how gender roles can have a negative effect on womens lives. Texas A M students Wood, Christensen, Hebl, and Rothgerber conducted a study on self concepts and role congruency (1997). Roles of males were defined by dominance and females were defined as intimate and communal (Wood et al, 1997). The research results showed signs that men had a more positive self concept when presented with situations similar to that of the normative sex role, i.e. dominance (Wood et al, 1997). Women had the similar tendency to have a positive self concept when presented with situations congruent with female roles (Wood et al, 1997). But what if a woman expressed more dominance? What if a womans lifestyle called for situations that required a more dominant, incongruent role norm? Eagly and Kassau postulated that women have a distinct disadvantage in leadership roles in the work environment due to expectations of their gender roles (2002). Women were perceived as less capable of being in a leadership role and evaluated negatively (Eagly and Kassau, 2002). This role congruity theory may explain many hardships experienced by females, such as the glass ceiling effect. Women may very well be hindered in their careers due to gender stereotypes. Men may also be judged for choosing career paths that are perceived as having more feminine qualities, such as nursing. Furthermore, men face criticism for staying at home with their children while their wive s work, also considered incongruent with current gender roles. With more and more women working, the standards for certain roles will inevitably have to change. Gender roles are just one small example of how social standards can affect our attitudes, behaviors, and how we live. As stated before, we have a multitude of roles that we live by throughout our lives. Each role comes with a unique set of social implications and prescribed behaviors. Each role becomes subtly stamped into our identity, integrated into who we are. I believe this quote is a wonderful summation and parallel analysis to the Stanford Prison Experiment and real world issues of roles and behaviors. Zimbardo states: In some ways, everyone will be a prisoner or a guard at some point in their life, because a guard is simply someone who limits the freedom of another person. Parents, spouses, and bosses do this all the time. And the recipients of this behavior? Well, they are the prisoners. (Slavich, 2009). Even though this statement may seem somewhat pessimistic, there may be a grain of truth in regards to the commitment to our roles and the consequences. We make little concessions to our freedoms every day. For example, we have obligations to work X amount of hours per week. Maybe we limit some of our behaviors out of respect for our spouses. Overall, I dont believe that most people can say that they get to do what they want to one hundred percent of the time. Our daily lives are dominated by rules and restrictions and that is not always a bad thing. But I believe it is important to examine closely the restrictions posed by the roles present in ones life. Zimbardo dared to ask the question: where does ones identity end and ones role begin? (1973). The two seem to be invariably intertwined, each having an effect on the other. The heavy weighing expectations of our roles seem to form parts of our identity. Are we, as people, greater than the sum of our roles? Or are we truly defined by our roles, and our roles alone? Does being a parent, or a spouse, or an employee of a certain company truly define you as a person? After reading Zimbardos The Lucifer Effect and watching many of his public speeches, I believe he would say that we have the power to use our roles for good. Also, that we are capable of transcending and breaking free from the negative, evil roles in our lives. Philip G. Zimbardo conducted one of the most important experiments in Social Psychology. The Stanford Prison Experiment gave us amazing insight into how extreme we will go in our actions and behaviors to fulfill our roles.
Wednesday, October 2, 2019
Essays --
This research proposal will be dealing with the growing problem of attention deficit hyperactive disorder, or also known commonly as ADHD, in the United States. ADHD has grown from the 1% of the childhood population in the 1970ââ¬â¢s to its current rate of 5% of the school age population according to National Survey of Childrenââ¬â¢s Health. That is a 400% increase over 40 years. With this type of increase, so has the increase of medication children are prescribed to help them cope with the disorder. This study will be looking at what kind of effect these medications are having on young children and, if any, the affects of the medication on the child meeting milestones in their education. H- Dietary eliminations from a child diagnosed with ADHA can have a notable positive effect. H1- Dietary eliminations from a child diagnosed with ADHA does not have a notable positive effect. Chapter 1: Introduction to research proposal. ADHD is defined by a persistent pattern of inattention and/or hyperactivity-impulsivity that is more frequently displayed and is more severe than is typically observed in individuals at comparable level of development (American Psychiatric Association, 2013). There are several characteristics that are present in ADHA that include hyperactive-impulsive or inattentive symptoms that must have been present in a childââ¬â¢s life before they reach seven years of age. Some impairment from the symptoms of ADHD must be present in at least two settings. A doctor must observe clear evidence of interference with developmentally appropriate social, academic or occupational functioning and the disturbance does not occur exclusively during the course of a Pervasive Developmental Disorder, Schizophrenia, or other Psychotic Disorders and... ...t even harder to study and find the true results of the effect they have on children. One that has been studied is known simply as Yellow Number 5 has been studied alone. The results are that they could not find a direct link to it and hyperactivity but it is the second most used dye in the United State. Yello Number 5 is called tartrazine and is commonly found in all of the following: Nabisco Cheese Nips Four Cheese; Frito-Lay Sun Chips Harvest Cheddar and other Frito-Lay products; some Hunt's Snack Pack Pudding products; Lucky Charms; Eggo waffles and other waffle products; some Pop-Tarts products; various Kraft macaroni and cheese products; Betty Crocker Hamburger Helper and other products; some Oscar Mayer Lunchables products; Hot Pockets Ham & Cheese; some Hostess cup cakes; some Betty Crocker frostings; some M&M's and Skittles products; some Gatorade products.
Tuesday, October 1, 2019
Beowulfs Manifestation of Hrothgars Lessons :: Epic Beowulf essays
Beowulf's Manifestation of Hrothgar's Lessons "We have not seen great things done in our time except by those who have been considered contemptible; the rest have failed." à à à à à à à à à à à à à à à à à --Machiavelli, The Prince à à à à à à à à In this statement --and in the rest of his major work, The Prince -- Machiavelli attempts to justify the cruelty of a leader; it is necessary, he seems to say, to be feared in order to succeed.à It is doubtful that the renaissance political theorist ever read the poem of Beowulf; in any case, he did not very much with its message. For if its titular hero followed the maxims of Machiavelli, Hrothgar, the leader of the Danes in the poem, contends that it will bring upon pride and, ultimately, Beowulf's downfall. Hrothgar's message is exactly contrasting to that of Machiavelli's. His political theory states that it is necessary to be good-willed to one's people and to refrain from being blinded by pride in order to be a successful leader. Fortunately for Beowulf, during his fifty-year reign as the ruler of the Geats he follows Hrothgar's sagacious lesson; consequently, he is compassionate leader who never lets his pride overcome his judgment. à Throughout his reign as the ruler of the Geats, Beowulf is a benevolent leader - bringing peace and power to his nation as Hrothgar instructs him to after the great warrior defeats Grendel's mother. Hrothgar relates to him a story about the Heremod, King of the Danes, who "brought little joy to the Danish people, only death and destruction" (1711-1712), and that "suffered in the end for having plagued his people" (1720-1721). That is, Hrothgar claims that one cannot be a successful leader unless one is virtuous ruler. Furthermore, he tells Beowulf to "learn from this and understand true value" (1723-1724). Therefore, Hrothgar's intends that this information be carried on with Beowulf. During his final moments, after he kills the treasure hording dragon, Beowulf reflects on his reign over the Geats, and those reflections demonstrate that he understands the importance of virtue and honor. He claims that he "cared for and stood by things in [his] keeping, never fomented qua rrels, never swore to a lie" (2736-2739). His goodwill and righteousness is highly regarded by the warrior, for he continues, "the Ruler of mankind need never blame me [.
Importance of Colloidal Dispersion in Pharmacy
Importance of colloidal dispersion in pharmacy Pharmaceutical Applications of colloids: Colloids are extensively used for modifying the properties of pharmaceutical agents. The most common property that is affected is the solubility of a drug . However, colloidal forms of many drugs exhibits substantially different properties when compared with traditional forms of these drugs. Certain medicinals have been found to possess unusual or increased therapeutic properties when formulated in the colloidal state.Another important pharmaceutical application of colloid is their use as drug delivery system. The most often used colloid type drug delivery systems include hydrogels, microspheres, microemulsions, liposomes, micelles, nanoparticles and nanocrystals. Here we mention the main characteristics of each colloidal delivery system. Hydrogels: Hydrogel is a colloidal gel in which water is the dispersion medium. It (also called aquagel) is a network of polymer chains that are hydrophilic, som etimes found as a colloidal gel in which water is the dispersion medium.Hydrogels are highly absorbent (they can contain over 99% water) natural or synthetic polymers. Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content. These hydrogels have the ability to sense changes of pH, temperature, or the concentration of metabolite and release their load as result of such a change Natural and synthetic hydrogels are used for wound healing, as scaffolds in tissue engineering, and as sustained- release delivery systems.When used as scaffolds for tissue engineering, hydrogels may contain human cells to stimulate tissue repair, since they are loaded with pharmaceutical ingredients, hydrogels provide a sustained drug release. Light-sensitive, pressure- responsive, and electro-sensitive hydrogels also have the potential to be used in drug delivery. Environmentally sensitive hydrogels include slow response time, limited biocompatibi lity, and biodegradability. Hydrogel used as sustained-release drug delivery systems. it provide absorption, desloughing and debriding capacities of necrotics and fibrotic tissue. ydrogels that are responsive to specific molecules, such as glucose or antigens can be used as biosensors, as well as in DDS. Also used in disposable diapers where they ââ¬Å"captureâ⬠urine, or in sanitary napkins, contact lenses (silicone hydrogels, polyacrylamides). Medical electrodes using hydrogels composed of cross-linked polymers (polyethylene oxide, polyAMPS and polyvinylpyrrolidone). hydrogel used as water gel explosives, rectal drug delivery and diagnosis. Other, less common uses include, breast implants, granules for holding soil moisture in arid areas, dressings for healing of burn or other hard-to-heal wounds.Wound gels are excellent for helping to create or maintain a moist environment, reservoirs in topical drug delivery; particularly ionic drugs, delivered by iontophoresis (see ion ex change resin), Common ingredients are e. g. polyvinyl alcohol, sodium polyacrylate, acrylate polymers and copolymers with an abundance of hydrophilic groups. Natural hydrogel materials are being investigated for tissue engineering; these materials include agarose, methylcellulose, hyaluronan, and other naturally derived polymers. However if the achievements of the past can be extrapolated into the future, it is likely that responsive hydrogels with a wide array of desirable properties will be forthcoming. Microparticles: Microparticles are small loaded microspheres of natural or synthetic polymers. Microparticles was initially developed as carriers for vaccines and anti-cancer drugs. More recently, novel properties of Microparticles have been developed to increase the efficiency of drug delivery and improve release profiles and drug targeting.Several investigations have focused on the development of methods of reducing the uptake of the nanoparticles by the cells of the reticuloendo thelial system and enhance their uptake by the targeted cells. Functional surface coatings of non-biodegradable carboxylated polystyrene or biodegradable poly (D,L- lactide-co-glycolide) microspheres with poly(L-lysine)-g-poly (ethylene glycol) (PLL-g-PEG) were investigated in attempts to shield them from nonspecific phagocytosis and to allow ligand- specific interactions via molecular recognisition.It was found that coatings of PLL-g-PEG- ligand conjugates provided for the specific targeting of microspheres to human blood- derived macrophages and dendritic cells while reducing non- specific phagocytosis. Microparticles can also be used to facilitate nontraditional routes of drug administration. It was found that Microparticles can be used to improve immunization using the mucosal route of administration of therapeutics. It was found in this study that mucosal route of administration of therapeutics can translocate to tissues in the systemic compartment of the immune system and prov oke immunological reactions. Micro & Nano-Emulsions:Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. Three distinct Microemulsions- oil external, water external, and middle phase- can be used for drug delivery, depending upon the type of the dug and the site of action. In contrast to Microparticles, which demonstrate distinct differences between the outer shell and core, microemulsions are usually formed with more or less homogeneous particles. Microemulsions are use for controlled release and targeted delivery of different pharmaceutics agents.For instance, microemulsions were used to deliver oligonucleotides (small fragments of DNA) specifically to ovarian cancer cells. In contrast to microemulsions, Nanoemulsions consist in very fine oil-in-water dispersions, having droplets diameter smaller than 100 nm. Compared to microemulsions, they are in a me ta stable state, and their structure depends on the history of the system. Nanoemulsions are very fragile systems. The nanoemulsions can find applications in skin care due to their good sensorial properties (rapid penetration, merging textures) and their biophysical properties (especially their hydrating power).Liposomes: Liposomes consist of an outer uni ââ¬â or multilamellar membrane and an inner liquid core. In most cases liposomes are formed with natural or synthetic phospholipids similar to those in cellular plasma membrane, because of this similarity, liposomes are easily utilized by cells. Liposomes can be loaded by pharmaceutical or other ingredients by two principal ways: Lipophilic substances can be associated with liposomal membrane, and hydrophilic substances can be dissolved in the inner liquid core of liposomes.To decrease uptake by the cells of the reticuloendothelial system and/or enhance their uptake by the targeted cells, the membrane of liposomes can be modifi ed by polymeric chains and/or targeting moieties or antibodies specific to the targeted cells, because they are relatively easy to prepare, biodegradable, and non- toxic, liposomes have found numerous applications as drug delivery systems. Liposomes are of colloidal dimensions and are preferentially taken up by the liver and spleen. Hence, principle of colloids is also used in targeted drug delivery system. Liposomes are used for drug delivery due to their unique properties.A liposome encapsulates a region on aqueous solution inside a hydrophobic membrane; dissolved hydrophilic solutes cannot readily pass through the lipids. Hydrophobic chemicals can be dissolved into the membrane, and in this way liposome can carry both hydrophobic molecules and hydrophilic molecules. To deliver the molecules to sites of action, the lipid bilayer can fuse with other bilayers such as the cell membrane, thus delivering the liposome contents. By making liposomes in a solution of DNA or drugs (which wo uld normally be unable to diffuse through the membrane) they can be (indiscriminately) delivered past the lipid bilayer.There are three types of liposomes ââ¬â MLV (multilamellar vesicles) SUV (Small Unilamellar Vesicles) and LUV (Large Unilamellar Vesicles). These are used to deliver different types of drugs. Liposomes are used as models for artificial cells. Liposomes can also be designed to deliver drugs in other ways. Liposomes that contain low (or high) pH can be constructed such that dissolved aqueous drugs will be charged in solution (i. e. , the pH is outside the drug's pI range). As the pH naturally neutralizes within the liposome (protons can pass through some membranes), the drug will also be neutralized, allowing it to freely pass through a membrane.These liposomes work to deliver drug by diffusion rather than by direct cell fusion. Another strategy for liposome drug delivery is to target endocytosis events. Liposomes can be made in a particular size range that makes them viable targets for natural macrophage phagocytosis. These liposomes may be digested while in the macrophage's phagosome, thus releasing its drug. Liposomes can also be decorated with opsonins and ligands to activate endocytosis in other cell types. The use of liposomes for transformation or transfection of DNA into a host cell is known as lipofection.In addition to gene and drug delivery applications, liposomes can be used as carriers for the delivery of dyes to textiles, pesticides to plants, enzymes and nutritional supplements to foods, and cosmetics to the skin. Another interesting property of liposomes is their natural ability to target cancer. The endothelial wall of all healthy human blood vessels is encapsulated by endothelial cells that are bound together by tight junctions. These tight junctions stop any large particles in the blood from leaking out of the vessel.Tumour vessels do not contain the same level of seal between cells and are diagnostically leaky. This abil ity is known as the Enhanced Permeability and Retention effect. Liposomes of certain sizes, typically less than 200 nm, can rapidly enter tumour sites from the blood, but are kept in the bloodstream by the endothelial wall in healthy tissue vasculature. Anti-cancer drugs such as Doxorubicin (Doxil), Camptothecin and Daunorubicin (Daunoxome) are currently being marketed in liposome delivery systems. Micelles: Micelles are similar to liposomes but they do not have an inner liquid compartment.Therefore they can be used as water- soluble biocompatible micro containers for the delivery of poorly soluble hydrophobic pharmaceuticals. Similar to liposomes their surface can be modified with antibodies (immunomicelles) or other targeting moieties providing the ability of micelles to specifically interact with their antigens. One type of micelles pluronic block copolymers, are recognized as pharmaceutical excipients listed in the U. S and British Pharmacopoeia. They have been extensively used in a variety of pharmaceutical formulations including delivery of low molecular mass drugs, polypeptides, and DNA.Furthermore, Pluronic block copolymers are versatile molecules that can be used as structural elements of polycation- based gene delivery system. Nanoparticles: Nanocapsules are sub-microscopic colloidal carrier systems composed of an oily or an aqueous core surrounded by a thin polymer membrane. Nanoparticles are the colloidal particulate systems with size ranging between 1-1000 nm. Based on the arrangement of drug and polymer matrix, nanoparticles can be classified into two types: nanospheres and nanocapsules . In nanospheres, rugs are either adsorbed or entrapped inside the polymeric matrix. In nanocapsules, drugs are confined to the inner liquid core while the external surface of nanoparticles is covered by the polymeric membrane. polymeric nanoparticles have gained considerable attention as potential drug delivery systems due to its targetability to particular organ /tissue and ability to deliver protein and peptide via oral route. Nanoparticles for drug delivery are generally made up of biocompatible and biodegradable polymers obtained from either natural or synthetic source.Natural polymers include chitosan, albumin, rosin, sodium alginate and gelatin while, synthetic polymers include poly (lactic acid) PLA, poly (D, L-glycolide), poly (lactide-co-glycolide), poly (caprolactones) (PCL) and poly (cyanoacrylates). The kinetics of drug release from nanoparticles depends on the strength of hydrophobic interactions between the polymer and drug and polymer degradation rate. The uptake and distribution of nanoparticles depend on its size. Nanoparticles of size ~10 nm are utilized for extended circulation, while ~100 and ~200 nm particles are utilized for passive targeting and intracellular drug delivery respectively.Though nanoparticles have many advantages over other conventional drug delivery systems certain properties like surface hydrophobicity and surface charge needs to be altered so as to increase the uptake of nanoparticles into cells. This can be done by judiciously manipulating the use of polymers. Coating the nanoparticles with chitosan which is positively charged significantly enhances the uptake and modulates the drug efflux of anticancer agents. Moreover, attachment of poly (ethylene glycol) moieties to the surface of nanoparticles increases the hydrophilicity and hence decreases the uptake by macrophages.Recent studies by Yoncheva et al. concluded that amino-pegylated poly (methyl vinyl ether-co-maleic anhydride) nanoparticles were able to cross the cell membrane of the absorptive enterocytes in a better way. Nanoparticles are characterized by a variety of techniques such as dynamic light scattering (DLS), electron microscopy (TEM or SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), matrix-assisted laser de sorption/ionization time-of-flight mass spectrometry (MALDI-TOF), and magnetic resonance (NMR).Two technologies can be used to develop such Nanocapsules: the interfacial polymerization of a monomer or the interfacial nano deposition of a performed polymer. Solid lipid nanoparticles are developed at the beginning of the 1990ââ¬â¢s as an alternative carrier system to emulsions, liposomes, and polymeric nanoparticles. They are used in particular in cosmetic and pharmaceutical formulations. A novel nano-particle based drug carrier for photodynamic therapy has been developed.This carrier can provide stable aqueous dispersion of hydrophobic photo-sensitizers; yet preserve the key step of photo generation of singlet oxygen, necessary for photodynamic action. Nanoparticles have also found applications as nonviral gene delivery systems. Advantages of nanoparticles a) Longer shelf-stability b) High carrier capacity c) Ability to incorporate hydrophilic and hydrophobic drug molecules d) Can be administered via different routes e) Longer clearance time f) Ability to sustain the release of drug ) Can be utilized for imaging studies h) Increase the bioavailability of drugs i) Targeted delivery of drugs at cellular and nuclear level j) Development of new medicines which are safer k) Prevent the multi-drug resistance mediated efflux of chemotherapeutic agents l) Product life extension Nanocrystals: Inorganic crystals that interface with biologic systems have recently attracted widespread interest in biology and medicine. To explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots), which are small (
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